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Jake Gyllenhaal’s Jamie Randall and Anne Hathaway’s Maggie Murdock had exceptional chemistry in the 2010 Edward Zwick movie,Love & Other Drugs. It was the exact reason why fans were excited when rumors surfaced about the duo reuniting for the second season of Netflix’s Emmy-winning anthology series,Beef. However, the latest rumors about the series are devastating forLove & Other Drugsfans.
According to reports, the series is looking to castMoon Knightstar Oscar Isaac andPromising Young Womanstar Carey Mulligan in Season 2. The second season will reportedly revolve around two feuding couples.
Love & Other DrugsFans Are Upset About The NewBeefRumors
Netflix’sBeefwon several accolades at the Primetime Emmys and the Golden Globes. The first season of the series showed how a road rage incident between characters played by Steven Yeun and Ali Wong escalates into a full-fledged feud.
In February 2024, reports emerged that Netflix was exploringa second season with an ensemble castincluding Charles Melton,Cailee Spaeny, Jake Gyllenhaal, and Anne Hathaway. Fans were excited about the prospect of Gyllenhaal and Hathaway reuniting afterBrokeback MountainandLove & Other Drugs.
“I love watching women kill it”: Anne Hathaway Revealed She Almost Became Barbie Before Margot Robbie Absolutely Mastered the Role
However,Deadlinenow reports that Netflix is eyeing a new pair instead of Hathaway and Gyllenhaal.Oscar IsaacandCarey Mulliganare reportedly in negotiations at Netflix to star in the second season. The pair had earlier acted together inDriveandInside Llewyn Davis. While some fans are disappointed over losing the earlier pair, others are excited to see the new two talents.
One fan on X shared that the new casting choice was meant to be after Isaac and Mulligan’s chemistry inInside Llewyn Davis. However, another fan shared that they should cancel the season if theEnemyactor wasn’t cast in the role. One fan shared that Gyllenhaal and Hathaway in the series would’ve been lit, but the current casting was good as well.
Another fan suggested that Isaac and Mulligan were aiming for Emmys after getting unlucky with the Oscars multiple times. One fan expressed disappointment over the much-awaitedLove & Other Drugsreunion getting canceled. Some of the fan reactions read:
This casting choice was meant to be!
— Bovada Casino (@Bovada_Casino)July 12, 2025
No Jake Gyllenhaal??? yeah just cancel itpic.twitter.com/tcIq0Qsd49
— ً (@tylerduran21)August 11, 2025
First casting would of been lit tbh but this is good too
— Khalil Underwood (@RealKhalilU)August 04, 2025
Well, I guess both Isaac and Mulligan can’t get Oscars any time soon, so they come after Emmys instead ? 😕
— Peter Rabbit’s Award Buzz (@PeterRabbit_4DX)August 08, 2025
Tbh would’ve liked to see Jake and Anne more but I am sure these two will be exceptional as well.
— CinemaBums (@Cinema_Bums)June 04, 2025
Love & Other Drugs reunion got cancelled.
— Rr. Dani Maziyar (@iwriteinsilence)August 20, 2025
Both Isaac and Mulligan are at a peak point in their careers. Isaac broke into two major franchises, Marvel andDune, and earned an Emmy nomination for HBO’sScenes from a Marriage. Carey Mulligan just lost her third Oscar nomination after her critically acclaimed performance in Bradley Cooper’sMaestro.
Jake Gyllenhaal and Anne Hathaway’s Chemistry InLove & Other DrugsWorked Exceptionally Well
Jake GyllenhaalandAnne Hathaway‘s 2010 film explored the relationship between Jamie Randall and Maggie Murdock, who suffers from an early onset of Parkinson’s disease. While Gyllenhaal and Hathaway worked together inBrokeback Mountain, they did not have much of an onscreen chemistry. When it came to this film, they shared a lot of steamy scenes between them.
Anne Hathaway Cried Every Single Day During Her Movie With Jake Gyllenhaal Because of Their Love Scenes
The two actors eventually developed a friendship andGyllenhaal made sure that his co-star was comfortablein the sx scenes in the movie (via Hollywood Life). Both actors agreed that the sx scenes helped them form a better relationship than what they had duringBrokeback Mountain.
In an interview with GQ Magazine, Gyllenhaal disclosed that they engaged in intimate heart-to-heart conversations during the film (via Cosmopolitan). This relationship between the actors connected well with the audience as well. While the film received mixed reviews from critics, it grossed $102 million at the box office against a budget of $30 million (via Box Office Mojo).
Love & Other Drugsis now available for streaming on Hulu.Beef Season 1is now available on Netflix.
Hashim Asraff
Senior Writer
Articles Published :3017
Hashim Asraff is a Senior Entertainment Writer at FandomWire, with over 2,800 articles published on celebrity culture, comic book movies, and major TV franchises. With a background in Sociology and a keen interest in pop culture, Hashim brings a unique lens to breaking news stories, character deep-dives, film rankings, and fan-driven perspectives.His coverage often includes the MCU, DCU, hit network shows, and celebrity profiles, giving readers a rich blend of entertainment and analysis. A longtime fan of crime and investigative series, Hashim has watched thousands of episodes of NCIS, Criminal Minds, Law & Order: SVU, Bones, Blue Bloods, and The RookieA passionate storyteller and wordsmith, Hashim has also worked as a ghostwriter and managed multiple social media handles. He brought his writing expertise to FandomWire to also pursue his lifelong love for cinema and television.
